치성각화낭종에서 receptor activator nuclear factor-κB Ligand(RANKL)와 osteoprotegrin(OPG) 발현에 관한 연구
Identification of Receptor Activator of Nuclear Factor-κB Ligand(RANKL) and Osteoprotegerin(OPG) in Odontogenic Keratocyst
안동길, 김성식, 하우연, 황대석, 김용덕, 신상훈, 김욱규, 김종렬, 정인교,
소속 상세정보
안동길 ( Ahn Dong-Kil ) - 부산대학교 치과대학 구강안면외과학교실
김성식 ( Kim Seong-Sik ) - 부산대학교 치과대학 치과교정학교실
하우연 ( Ha Woo-Hun ) - 부산대학교 치과대학 구강안면외과학교실
황대석 ( Hwang Dae-Seok ) - 부산대학교 치과대학 구강안면외과학교실
김용덕 ( Kim Yong-Deok ) - 부산대학교 치과대학 구강안면외과학교실
신상훈 ( Shin Sang-Hun ) - 부산대학교 치과대학 구강안면외과학교실
김욱규 ( Kim Uk-Kyu ) - 부산대학교 치과대학 구강안면외과학교실
김종렬 ( Kim Jong-Ryoul ) - 부산대학교 치과대학 구강안면외과학교실
정인교 ( Jung In-Kyo ) - 부산대학교 치과대학 구강안면외과학교실
KMID : 0360120070290010000
Abstract
The odontogenic keratocyst(OKC) is a common developmental odontogenic cyst and represents approximately 11% of odontogenic cysts. It is decided by microscopic and histopathologic determinant rather than by clinical appearance. In this study, expression of RANKL and OPG in OKC in relation to age and gender of patient and recurrence, location of lesion were examined through immuno- histochemical study.The RANKL and OPG antibody staining were used. The obtained result were as follow.1. Positive immunoreactivity to RANKL/OPG in all specimens was found.2. There was no significant difference in immunohistochemical expression of RANKL relating to recurrence, location of OKCs and age, gender of patients.3. There was no significant difference in immunohistochemical expression of OPG relating to recurrence, location of OKCs and age, gender of patients.From above results, it is suggested that activation of osteoclasts by RANKL is an important mechanism by which OKCs cause bone destruction.
키워드
OKC;RANKL;OPG
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